CBD and the Endocannabinoid System

The endocannabinoid system is a more recent scientific discovery, and it is responsible for two important activities—controlling pleasure, pain, and secondly to help the body heal when faced with disease or bad health. CBD and the endocannabinoid system work in complex ways, and over the last 30 years there has been a surge in research on the subject. While there is still a great amount of data to be discovered, people are finding out all over about the health benefits of CBD on their own. 


In the late 1980s, research uncovered the Cannabinoid 1 receptor, and shortly after the Cannabinoid 2 receptor was uncovered. Respectively they are known as CB1 and CB2 for short. Around this time simultaneous research was marking the first endocannabinoid signaling molecule, arachidonoyl ethanolamide (AEA). 


There cannot be said enough about the importance of the endocannabinoid system. Because of its restorative properties, CBD is now known as a major agent that takes part in regulating well-being of the body. Pacher and Kunos published an article in a 2013 publication stating that the endocannabinoid system has a wide range of healing potential in almost all issues that can negatively affect the body, including: obesity, diabetes, inflammation, cardiovascular problems, cancer, pain, skin disease, psychiatric disorders, nausea and vomiting, and more. 


Currently, we understand the endocannabinoid system in the following way:


  • There are two receptors: CB1 and CB2.
  • There are two signaling molecules: arachidonoyl ethanolamide (AEA), and 2 arachidonoyl glycerol (2-AG). 
  • There are 5 Enzymes: DAGL-α (for synthesis of 2-AG), DAGL-β (for synthesis of 2-AG),MAGL (for breakdown of 2-AG), FAAH (for breakdown of AEA), and NAPE selective phospholipase-D (for synthesis of AEA)


Furthermore, there are alternate ways that AEA synthesizes in your body. It should also be noted that the endocannabinoid system works outside its own boundaries. It isn’t surprising that it appears to interact in a major way with other non cannabinoid systems inside your body—miraculously regulating health problems and general well-being. It can affect your endorphin system, the immune system, and systems affecting pain. 


This gives the endocannabinoid system the potential to control things like inflammation, chronic pain, bone health, mood, hormonal balance, and brain health. There are several special and quite breathtaking reactions caused by the endocannabinoid system. AEA and 2-AG are important substances in the body. They are closely related to CB1 receptors, and CB2 receptors in your central nervous system. 

Tips on How to Use CBD vs THC

There are a number of oral and edible CBD treatments available. Choosing a CBD dominant medicine is more effective in many ways than simply using cannabis that is high in THC. The effects are more central to the body, and come without the mind altering head high. Many people describe it as a “body high.” 


We all know that when the body feels relaxation, the mind may follow, which could be why so many people report that CBD can cure anxiety. It can improve your general mood and give you a mood lift without being “stoned.” A small portion of people who use CBD may be very sensitive to THC, and may report negative effects that are more common with THC rich strains of cannabis. Because of this, beginners should be wary of driving or operating heavy machinery when first starting out. It’s better to wait until you are more familiar with the effects before attempting those activities. 


Another problem with THC for health benefits is that it affects each person differently. One patient may feel relaxed and happy, while the next can become anxious and worried. There are a number of factors that are responsible for the effect of the drug. This can include the amount taken, the kind of medicine taken, as well as personal factors like your weight, diet, emotional well-being, and your history with the drug. 


Oral and Edible CBD Treatments

A large spike in CBD’s popularity has set of a revival of the use of CBD as a cure-all medicine. It opened up a whole new world to patients and health care practitioners alike. Below is a quick rundown of some of the most common ways to ingest CBD to achieve a non-psychoactive benefit for your health. It has really paved the way to a whole new slew of benefits from cannabis and hemp without the problem of being impared in any way. 


You can choose to smoke or vaporize CBD. The medicine will enter your bloodstream directly from your lungs. It works immediately and can last anywhere from 2 to 4 hours on average. 


Oral ingestion is slower than inhalation, and usually reaches full effect within 1 to 2 hours. It can last anywhere from 30 minutes to over 2 hours. Be careful when ingesting CBD orally if you are unfamiliar with the effects. 


TInctures, candies that dissolve in your mouth, and other types of oral ingestion will enter your bloodstream through a mucous membrane. It can take anywhere from 15 minutes to an hour to set on, and can last from 4 to 6 hours. 


This is typically a rub that is applied directly to your skin for local pain. It comes in a baum or salve. It doesn’t enter your bloodstream and can take 15 minutes to set on, lasting anywhere from 2 to 4 hours on average.